Topological optimization for designing patient-specific large craniofacial segmental bone replacements

Alok Sutradhar, Glaucio H. Paulino, Michael J. Miller, Tam H. Nguyen

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Restoring normal function and appearance after massive facial injuries with bone loss is an important unsolved problem in surgery. An important limitation of the current methods is heuristic ad hoc design of bone replacements by the operating surgeon at the time of surgery. This problem might be addressed by incorporating a computational method known as topological optimization into routine surgical planning. We tested the feasibility of using a multiresolution three-dimensional topological optimization to design replacements for massive midface injuries with bone loss. The final solution to meet functional requirements may be shaped differently than the natural human bone but be optimized for functional needs sufficient to support full restoration using a combination of soft tissue repair and synthetic prosthetics. Topological optimization for designing facial bone tissue replacements might improve current clinical methods and provide essential enabling technology to translate generic bone tissue engineering methods into specific solutions for individual patients.

Original languageEnglish (US)
Pages (from-to)13222-13227
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number30
StatePublished - Jul 27 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


  • Bone tissue engineering
  • Craniofacial reconstruction
  • Massive facial injury
  • Midface reconstruction
  • Segmental bone defects


Dive into the research topics of 'Topological optimization for designing patient-specific large craniofacial segmental bone replacements'. Together they form a unique fingerprint.

Cite this