Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line

Richard W. Scott; Thomas F. Vogt; Mary Ellen Croke; Shirley M. Tilghman

doi:10.1038/310562a0

Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line

Richard W. Scott, Thomas F. Vogt, Mary Ellen Croke, Shirley M. Tilghman

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Abstract

To identify cis-acting DNA elements involved in the activation of the α-fetoprotein gene during differentiation, modified copies of the gene were introduced into murine F9 embryonal carcinoma cells. The differentiation of the transformants to either parietal or visceral endoderm was accompanied by induction of the exogenous template in a manner qualitatively, but not quantitatively, identical to that of the endogenous α-fetoprotein gene.

Original language	English (US)
Pages (from-to)	562-567
Number of pages	6
Journal	Nature
Volume	310
Issue number	5978
DOIs	https://doi.org/10.1038/310562a0
State	Published - 1984

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title = "Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line",

abstract = "To identify cis-acting DNA elements involved in the activation of the α-fetoprotein gene during differentiation, modified copies of the gene were introduced into murine F9 embryonal carcinoma cells. The differentiation of the transformants to either parietal or visceral endoderm was accompanied by induction of the exogenous template in a manner qualitatively, but not quantitatively, identical to that of the endogenous α-fetoprotein gene.",

author = "Scott, {Richard W.} and Vogt, {Thomas F.} and Croke, {Mary Ellen} and Tilghman, {Shirley M.}",

year = "1984",

doi = "10.1038/310562a0",

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T1 - Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line

AU - Scott, Richard W.

AU - Vogt, Thomas F.

AU - Croke, Mary Ellen

AU - Tilghman, Shirley M.

PY - 1984

Y1 - 1984

N2 - To identify cis-acting DNA elements involved in the activation of the α-fetoprotein gene during differentiation, modified copies of the gene were introduced into murine F9 embryonal carcinoma cells. The differentiation of the transformants to either parietal or visceral endoderm was accompanied by induction of the exogenous template in a manner qualitatively, but not quantitatively, identical to that of the endogenous α-fetoprotein gene.

AB - To identify cis-acting DNA elements involved in the activation of the α-fetoprotein gene during differentiation, modified copies of the gene were introduced into murine F9 embryonal carcinoma cells. The differentiation of the transformants to either parietal or visceral endoderm was accompanied by induction of the exogenous template in a manner qualitatively, but not quantitatively, identical to that of the endogenous α-fetoprotein gene.

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Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line

Abstract

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