Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line

Richard W. Scott, Thomas F. Vogt, Mary Ellen Croke, Shirley M. Tilghman

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

To identify cis-acting DNA elements involved in the activation of the α-fetoprotein gene during differentiation, modified copies of the gene were introduced into murine F9 embryonal carcinoma cells. The differentiation of the transformants to either parietal or visceral endoderm was accompanied by induction of the exogenous template in a manner qualitatively, but not quantitatively, identical to that of the endogenous α-fetoprotein gene.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalNature
Volume310
Issue number5978
DOIs
StatePublished - 1984

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line'. Together they form a unique fingerprint.

  • Cite this