Tinker, tailor, antiviral: RNA virus inhibition by induced recombination

Emmanuelle Pitre; Aartjan J.W. te Velthuis

doi:10.1016/j.tibs.2022.01.003

Tinker, tailor, antiviral: RNA virus inhibition by induced recombination

Emmanuelle Pitre, Aartjan J.W. te Velthuis

Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Nucleotide analogs can help to combat RNA virus growth by stalling the viral RNA polymerase or by introducing lethal mutations into the viral genome. Janissen and Woodman et al. have used single-molecule, sequencing, and virological methods to reveal that antiviral T-1106 provides a third mechanism of counterattack: inducing recombination.

Original language	English (US)
Pages (from-to)	456-458
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	47
Issue number	6
DOIs	https://doi.org/10.1016/j.tibs.2022.01.003
State	Published - Jun 2022

All Science Journal Classification (ASJC) codes

Molecular Biology
Biochemistry

Keywords

RNA polymerase
magnetic tweezers
recombination
template switching

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10.1016/j.tibs.2022.01.003

Cite this

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title = "Tinker, tailor, antiviral: RNA virus inhibition by induced recombination",

abstract = "Nucleotide analogs can help to combat RNA virus growth by stalling the viral RNA polymerase or by introducing lethal mutations into the viral genome. Janissen and Woodman et al. have used single-molecule, sequencing, and virological methods to reveal that antiviral T-1106 provides a third mechanism of counterattack: inducing recombination.",

keywords = "RNA polymerase, magnetic tweezers, recombination, template switching",

author = "Emmanuelle Pitre and {te Velthuis}, {Aartjan J.W.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = jun,

doi = "10.1016/j.tibs.2022.01.003",

language = "English (US)",

volume = "47",

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journal = "Trends in Biochemical Sciences",

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T1 - Tinker, tailor, antiviral

T2 - RNA virus inhibition by induced recombination

AU - Pitre, Emmanuelle

AU - te Velthuis, Aartjan J.W.

PY - 2022/6

Y1 - 2022/6

N2 - Nucleotide analogs can help to combat RNA virus growth by stalling the viral RNA polymerase or by introducing lethal mutations into the viral genome. Janissen and Woodman et al. have used single-molecule, sequencing, and virological methods to reveal that antiviral T-1106 provides a third mechanism of counterattack: inducing recombination.

AB - Nucleotide analogs can help to combat RNA virus growth by stalling the viral RNA polymerase or by introducing lethal mutations into the viral genome. Janissen and Woodman et al. have used single-molecule, sequencing, and virological methods to reveal that antiviral T-1106 provides a third mechanism of counterattack: inducing recombination.

KW - RNA polymerase

KW - magnetic tweezers

KW - recombination

KW - template switching

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U2 - 10.1016/j.tibs.2022.01.003

DO - 10.1016/j.tibs.2022.01.003

M3 - Short survey

C2 - 35123872

AN - SCOPUS:85124020439

SN - 0968-0004

VL - 47

SP - 456

EP - 458

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 6

ER -

Tinker, tailor, antiviral: RNA virus inhibition by induced recombination

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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