Tinker, tailor, antiviral: RNA virus inhibition by induced recombination

Emmanuelle Pitre, Aartjan J.W. te Velthuis

Research output: Contribution to journalShort surveypeer-review


Nucleotide analogs can help to combat RNA virus growth by stalling the viral RNA polymerase or by introducing lethal mutations into the viral genome. Janissen and Woodman et al. have used single-molecule, sequencing, and virological methods to reveal that antiviral T-1106 provides a third mechanism of counterattack: inducing recombination.

Original languageEnglish (US)
Pages (from-to)456-458
Number of pages3
JournalTrends in Biochemical Sciences
Issue number6
StatePublished - Jun 2022

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry


  • RNA polymerase
  • magnetic tweezers
  • recombination
  • template switching


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