Time and length scales of autocrine signals in three dimensions

Mathieu Coppey, Alexander M. Berezhkovskii, Stuart C. Sealfon, Stanislav Y. Shvartsman

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.

Original languageEnglish (US)
Pages (from-to)1917-1922
Number of pages6
JournalBiophysical Journal
Volume93
Issue number6
DOIs
StatePublished - Sep 2007

All Science Journal Classification (ASJC) codes

  • Biophysics

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