Time and length scales of autocrine signals in three dimensions

Mathieu Coppey; Alexander M. Berezhkovskii; Stuart C. Sealfon; Stanislav Y. Shvartsman

doi:10.1529/biophysj.107.109736

Time and length scales of autocrine signals in three dimensions

Mathieu Coppey, Alexander M. Berezhkovskii, Stuart C. Sealfon, Stanislav Y. Shvartsman

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.

Original language	English (US)
Pages (from-to)	1917-1922
Number of pages	6
Journal	Biophysical Journal
Volume	93
Issue number	6
DOIs	https://doi.org/10.1529/biophysj.107.109736
State	Published - Sep 2007

All Science Journal Classification (ASJC) codes

Biophysics

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10.1529/biophysj.107.109736

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abstract = "A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.",

author = "Mathieu Coppey and Berezhkovskii, {Alexander M.} and Sealfon, {Stuart C.} and Shvartsman, {Stanislav Y.}",

note = "Funding Information: This study was supported by the National Institutes of Health contract HHSN266200500021C ADB No. N01-AI-50021 and the Intramural Research Program of the National Institutes of Health, Center for Information Technology.",

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AU - Sealfon, Stuart C.

AU - Shvartsman, Stanislav Y.

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N2 - A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.

AB - A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.

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Time and length scales of autocrine signals in three dimensions

Abstract

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