TY - JOUR
T1 - Thymic selection of T-cell receptors as an extreme value problem
AU - Košmrlj, Andrej
AU - Chakraborty, Arup K.
AU - Kardar, Mehran
AU - Shakhnovich, Eugene I.
PY - 2009/8/7
Y1 - 2009/8/7
N2 - T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions).
AB - T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions).
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U2 - 10.1103/PhysRevLett.103.068103
DO - 10.1103/PhysRevLett.103.068103
M3 - Article
C2 - 19792616
AN - SCOPUS:68849127884
SN - 0031-9007
VL - 103
JO - Physical review letters
JF - Physical review letters
IS - 6
M1 - 068103
ER -