The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome

Yi Ren, Qing Yu He, Jianqing Fan, Brian Jones, Yuan Zhou, Yi Xie, Chung Yan Cheung, Adrian Wu, Jen Fu Chiu, J. S.Malik Peiris, Paul Kwong Hang Tam

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Severe acute respiratory syndrome (SARS) is a new infectious disease with a global impact. Understanding its pathogenesis and developing specific diagnostic methods for its early diagnosis are crucial for the effective management and control of this disease. By using proteomic technology, truncated forms of α1-antitrypsin (TF-α1-AT) were found to increase significantly and consistently in sera of SARS patients compared to control subjects. The result showed a sensitivity of 100% for SARS patients and a specificity of 92.8% for controls. Furthermore, the levels of these proteins significantly correlated with certain clinico-pathological parameters. The dramatic increase in TF-α1-AT may be the result of degradation of α1-AT. As α1-AT plays an important role in the protection of lung function, its degradation may be an important factor in the pathogenesis of SARS. These findings indicate that increased TF-α1-AT may be therapeutically relevant, and may also be a useful biological marker for the diagnosis of SARS.

Original languageEnglish (US)
Pages (from-to)3477-3484
Number of pages8
JournalProteomics
Volume4
Issue number11
DOIs
StatePublished - Nov 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Keywords

  • Biomarker
  • Complement 4
  • Serum amyloid A
  • Severe acute respiratory syndrome
  • α-antitrypsin

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