The use of humanized mice for studies of viral pathogenesis and immunity

Florian Douam, Alexander Ploss

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Humanized mice, that is, animals engrafted with human tissues and/or expressing human genes, have been instrumental in improving our understanding of the pathogenesis and immunological processes that define some of the most challenging human-tropic viruses. In particular, mice engrafted with components of a human immune system (HIS) offer unprecedented opportunities for mechanistic studies of human immune responses to infection. Here, we provide a brief overview of the current panel of HIS mouse models available and cite recent examples of how such humanized animals have been used to study immune responses and pathogenesis elicited by human-tropic viruses. Finally, we will outline some of the challenges that lay ahead and strategies to improve and refine humanized mice with the goal of more accurately recapitulating human immune responses to viral infection.

Original languageEnglish (US)
Pages (from-to)62-71
Number of pages10
JournalCurrent Opinion in Virology
Volume29
DOIs
StatePublished - Apr 2018

All Science Journal Classification (ASJC) codes

  • Virology

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