The use of HIV-1 protease structure in inhibitor design

Robert E. Babine; Nan Zhang; Alex R. Jurgens; Steven R. Schow; Parimal R. Desai; John C. James; M. F. Semmelhack

doi:10.1016/S0960-894X(01)81194-X

The use of HIV-1 protease structure in inhibitor design

Robert E. Babine
, Nan Zhang
, Alex R. Jurgens
, Steven R. Schow
, Parimal R. Desai
, John C. James
, M. F. Semmelhack

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The X-ray structure of HIV-1 protease and molecular dynamics studies were used in the design of pseudo-symmetrical enzyme inhibitors 1 and 2. Short bidirectional syntheses of these compounds are described.

Original language	English (US)
Pages (from-to)	541-546
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(01)81194-X
State	Published - Jun 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)81194-X

Cite this

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title = "The use of HIV-1 protease structure in inhibitor design",

abstract = "The X-ray structure of HIV-1 protease and molecular dynamics studies were used in the design of pseudo-symmetrical enzyme inhibitors 1 and 2. Short bidirectional syntheses of these compounds are described.",

author = "Babine, \{Robert E.\} and Nan Zhang and Jurgens, \{Alex R.\} and Schow, \{Steven R.\} and Desai, \{Parimal R.\} and James, \{John C.\} and Semmelhack, \{M. F.\}",

year = "1992",

month = jun,

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AU - Babine, Robert E.

AU - Zhang, Nan

AU - Jurgens, Alex R.

AU - Schow, Steven R.

AU - Desai, Parimal R.

AU - James, John C.

AU - Semmelhack, M. F.

PY - 1992/6

Y1 - 1992/6

N2 - The X-ray structure of HIV-1 protease and molecular dynamics studies were used in the design of pseudo-symmetrical enzyme inhibitors 1 and 2. Short bidirectional syntheses of these compounds are described.

AB - The X-ray structure of HIV-1 protease and molecular dynamics studies were used in the design of pseudo-symmetrical enzyme inhibitors 1 and 2. Short bidirectional syntheses of these compounds are described.

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UR - https://www.scopus.com/pages/publications/0026658493#tab=citedBy

U2 - 10.1016/S0960-894X(01)81194-X

DO - 10.1016/S0960-894X(01)81194-X

M3 - Article

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EP - 546

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

The use of HIV-1 protease structure in inhibitor design

Abstract

All Science Journal Classification (ASJC) codes

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