Abstract
The X-ray structure of HIV-1 protease and molecular dynamics studies were used in the design of pseudo-symmetrical enzyme inhibitors 1 and 2. Short bidirectional syntheses of these compounds are described.
Original language | English (US) |
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Pages (from-to) | 541-546 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 2 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1992 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry