The use of HIV-1 protease structure in inhibitor design

Robert E. Babine, Nan Zhang, Alex R. Jurgens, Steven R. Schow, Parimal R. Desai, John C. James, M. F. Semmelhack

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The X-ray structure of HIV-1 protease and molecular dynamics studies were used in the design of pseudo-symmetrical enzyme inhibitors 1 and 2. Short bidirectional syntheses of these compounds are described.

Original languageEnglish (US)
Pages (from-to)541-546
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
StatePublished - Jun 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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