The use of computational modeling to link sensory processing with behavior in drosophila

Jan Clemens, Mala Murthy

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Understanding both how the brain represents information and how these representations drive behaviour are major goals of systems neuroscience. Even though genetic model organisms like Drosophila grant unprecedented experimental access to the nervous system for manipulating and recording neural activity, the complexity of natural stimuli and natural behaviours still poses significant challenges for solving the connections between neural activity and behaviour. Here, we advocate for the use of computational modelling to complement (and enhance) the Drosophila toolkit. We first lay out a modelling framework for making sense of the relation between natural sensory stimuli, neuronal responses, and natural behaviour. We then highlight how this framework can be used to reveal how neural circuits drive behaviour, using selected case studies.

Original languageEnglish (US)
Title of host publicationDecoding Neural Circuit Structure and Function
Subtitle of host publicationCellular Dissection Using Genetic Model Organisms
PublisherSpringer International Publishing
Number of pages20
ISBN (Electronic)9783319573632
ISBN (Print)9783319573625
StatePublished - Jul 24 2017

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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