TY - JOUR
T1 - The talin wags the dog
T2 - New insights into integrin activation
AU - Cram, Erin J.
AU - Schwarzbauer, Jean E.
PY - 2004/2
Y1 - 2004/2
N2 - Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.
AB - Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.
UR - http://www.scopus.com/inward/record.url?scp=0442323565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0442323565&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2003.12.009
DO - 10.1016/j.tcb.2003.12.009
M3 - Short survey
C2 - 15106607
AN - SCOPUS:0442323565
SN - 0962-8924
VL - 14
SP - 55
EP - 57
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 2
ER -