The talin wags the dog: New insights into integrin activation

Erin J. Cram, Jean E. Schwarzbauer

Research output: Contribution to journalShort surveypeer-review

38 Scopus citations


Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.

Original languageEnglish (US)
Pages (from-to)55-57
Number of pages3
JournalTrends in Cell Biology
Issue number2
StatePublished - Feb 2004

All Science Journal Classification (ASJC) codes

  • Cell Biology


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