TY - JOUR
T1 - The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health
AU - Domingue, Benjamin W.
AU - Belsky, Daniel W.
AU - Fletcher, Jason M.
AU - Conley, Dalton
AU - Boardman, Jason D.
AU - Harris, Kathleen Mullan
N1 - Funding Information:
on Aging Grants R01AG032282 and P30AG028716. D.C. is supported by a Russell Sage Foundation grant on “GxE and Health Inequality Across the Lifecourse” (83-15-29).
Funding Information:
ACKNOWLEDGMENTS. This research benefitted from GWAS results made publicly available by Social Science Genetic Association Consortium and Genetic Investigation of Anthropometric Traits. We acknowledge Matthew Robinson for helpful comments and Robbee Wedow, Matthew McQueen, Joyce Tabor, Heather Highland, and Christy Avery for assistance with the Add Health genetic sample. This research uses Add Health GWAS data under the stewardship of K.M.H. and funded by NIH–Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Grants R01 HD073342 (to K.M.H.) and R01 HD060726 (to J.D.B., Matthew B. McQueen, and K.M.H.). Add Health is a program project directed by K.M.H. and designed by J. Richard Udry, Peter S. Bearman, and K.M.H. at the University of North Carolina at Chapel Hill, and funded by NICHD Grant P01 HD31921, with cooperative funding from 23 other federal agencies and foundations. D.W.B. is supported by a Jacobs Foundation Early Career Research Fellowship and by National Institute
Funding Information:
This research benefitted from GWAS results made publicly available by Social Science Genetic Association Consortium and Genetic Investigation of Anthropometric Traits. We acknowledge Matthew Robinson for helpful comments and Robbee Wedow, Matthew McQueen, Joyce Tabor, Heather Highland, and Christy Avery for assistance with the Add Health genetic sample. This research uses Add Health GWAS data under the stewardship of K.M.H. and funded by NIH–Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Grants R01 HD073342 (to K.M.H.) and R01 HD060726 (to J.D.B., Matthew B. McQueen, and K.M.H.). Add Health is a program project directed by K.M.H. and designed by J. Richard Udry, Peter S. Bearman, and K.M.H. at the University of North Carolina at Chapel Hill, and funded by NICHD Grant P01 HD31921, with cooperative funding from 23 other federal agencies and foundations. D.W.B. is supported by a Jacobs Foundation Early Career Research Fellowship and by National Institute on Aging Grants R01AG032282 and P30AG028716. D.C. is supported by a Russell Sage Foundation grant on “GxE and Health Inequality Across the Lifecourse” (83-15-29).
PY - 2018/1/23
Y1 - 2018/1/23
N2 - Humans tend to form social relationships with others who resemble them. Whether this sorting of like with like arises from historical patterns of migration, meso-level social structures in modern society, or individual-level selection of similar peers remains unsettled. Recent research has evaluated the possibility that unobserved genotypes may play an important role in the creation of homophilous relationships. We extend this work by using data from 5,500 adolescents from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine genetic similarities among pairs of friends. Although there is some evidence that friends have correlated genotypes, both at the whole-genome level as well as at trait-associated loci (via polygenic scores), further analysis suggests that meso-level forces, such as school assignment, are a principal source of genetic similarity between friends. We also observe apparent social–genetic effects in which polygenic scores of an individual’s friends and schoolmates predict the individual’s own educational attainment. In contrast, an individual’s height is unassociated with the height genetics of peers.
AB - Humans tend to form social relationships with others who resemble them. Whether this sorting of like with like arises from historical patterns of migration, meso-level social structures in modern society, or individual-level selection of similar peers remains unsettled. Recent research has evaluated the possibility that unobserved genotypes may play an important role in the creation of homophilous relationships. We extend this work by using data from 5,500 adolescents from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine genetic similarities among pairs of friends. Although there is some evidence that friends have correlated genotypes, both at the whole-genome level as well as at trait-associated loci (via polygenic scores), further analysis suggests that meso-level forces, such as school assignment, are a principal source of genetic similarity between friends. We also observe apparent social–genetic effects in which polygenic scores of an individual’s friends and schoolmates predict the individual’s own educational attainment. In contrast, an individual’s height is unassociated with the height genetics of peers.
KW - BMI
KW - Educational attainment
KW - GWAS
KW - Polygenic score
KW - Social–genetic effect
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U2 - 10.1073/pnas.1711803115
DO - 10.1073/pnas.1711803115
M3 - Article
C2 - 29317533
AN - SCOPUS:85040861053
SN - 0027-8424
VL - 115
SP - 702
EP - 707
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 4
ER -