TY - JOUR
T1 - The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin
AU - Frauenfelder, Hans
AU - McMahon, Benjamin H.
AU - Austin, Robert Hamilton
AU - Chu, Kelvin
AU - Groves, John Taylor
PY - 2001/2/27
Y1 - 2001/2/27
N2 - The grail of protein science is the connection between structure and function. For myoglobin (Mb) this goal is close. Described as only a passive dioxygen storage protein in texts, we argue here that Mb is actually an allosteric enzyme that can catalyze reactions among small molecules. Studies of the structural, spectroscopic, and kinetic properties of Mb lead to a model that relates structure, energy landscape, dynamics, and function. Mb functions as a miniature chemical reactor, concentrating and orienting diatomic molecules such as NO, CO, O2, and H2O2 in highly conserved internal cavities. Reactions can be controlled because Mb exists in distinct taxonomic substates with different catalytic properties and connectivities of internal cavities.
AB - The grail of protein science is the connection between structure and function. For myoglobin (Mb) this goal is close. Described as only a passive dioxygen storage protein in texts, we argue here that Mb is actually an allosteric enzyme that can catalyze reactions among small molecules. Studies of the structural, spectroscopic, and kinetic properties of Mb lead to a model that relates structure, energy landscape, dynamics, and function. Mb functions as a miniature chemical reactor, concentrating and orienting diatomic molecules such as NO, CO, O2, and H2O2 in highly conserved internal cavities. Reactions can be controlled because Mb exists in distinct taxonomic substates with different catalytic properties and connectivities of internal cavities.
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U2 - 10.1073/pnas.041614298
DO - 10.1073/pnas.041614298
M3 - Article
C2 - 11226246
AN - SCOPUS:0035957014
SN - 0027-8424
VL - 98
SP - 2370
EP - 2374
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 5
ER -