The role of metabolism in bacterial persistence

Stephanie M. Amato, Christopher H. Fazen, Theresa C. Henry, Wendy W.K. Mok, Mehmet A. Orman, Elizabeth L. Sandvik, Katherine G. Volzing, Mark P. Brynildsen

Research output: Contribution to journalShort surveypeer-review

180 Scopus citations


Bacterial persisters are phenotypic variants with extraordinary tolerances toward antibiotics. Persister survival has been attributed to inhibition of essential cell functions during antibiotic stress, followed by reversal of the process and resumption of growth upon removal of the antibiotic. Metabolism plays a critical role in this process, since it participates in the entry, maintenance, and exit from the persister phenotype. Here, we review the experimental evidence that demonstrates the importance of metabolism to persistence, highlight the successes and potential of targeting metabolism in the search for anti-persister therapies, and discuss the current methods and challenges to understand persister physiology.

Original languageEnglish (US)
Article number70
JournalFrontiers in Microbiology
Issue numberMAR
StatePublished - 2014

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Microbiology


  • Antibiotic tolerance
  • Bacterial persistence
  • Metabolism
  • Nutrient environment
  • PpGpp


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