The role of a conserved threonine residue in the leader peptide of lasso peptide precursors

Si Jia Pan, Jakub Rajniak, Mikhail O. Maksimov, A. James Link

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The conserved threonine (Thr) residue in the penultimate position of the leader peptide of lasso peptides microcin J25 and capistruin can be effectively replaced by several amino acids close in size and shape to Thr. These findings suggest a model for lasso peptide biosynthesis in which the Thr sidechain is a recognition element for the lasso peptide maturation machinery.

Original languageEnglish (US)
Pages (from-to)1880-1882
Number of pages3
JournalChemical Communications
Volume48
Issue number13
DOIs
StatePublished - Jan 16 2012

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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