The role of a conserved threonine residue in the leader peptide of lasso peptide precursors

Si Jia Pan; Jakub Rajniak; Mikhail O. Maksimov; A. James Link

doi:10.1039/c2cc17211a

The role of a conserved threonine residue in the leader peptide of lasso peptide precursors

Si Jia Pan, Jakub Rajniak, Mikhail O. Maksimov, A. James Link

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43 Scopus citations

Abstract

The conserved threonine (Thr) residue in the penultimate position of the leader peptide of lasso peptides microcin J25 and capistruin can be effectively replaced by several amino acids close in size and shape to Thr. These findings suggest a model for lasso peptide biosynthesis in which the Thr sidechain is a recognition element for the lasso peptide maturation machinery.

Original language	English (US)
Pages (from-to)	1880-1882
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	13
DOIs	https://doi.org/10.1039/c2cc17211a
State	Published - Jan 16 2012

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c2cc17211a

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abstract = "The conserved threonine (Thr) residue in the penultimate position of the leader peptide of lasso peptides microcin J25 and capistruin can be effectively replaced by several amino acids close in size and shape to Thr. These findings suggest a model for lasso peptide biosynthesis in which the Thr sidechain is a recognition element for the lasso peptide maturation machinery.",

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AB - The conserved threonine (Thr) residue in the penultimate position of the leader peptide of lasso peptides microcin J25 and capistruin can be effectively replaced by several amino acids close in size and shape to Thr. These findings suggest a model for lasso peptide biosynthesis in which the Thr sidechain is a recognition element for the lasso peptide maturation machinery.

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The role of a conserved threonine residue in the leader peptide of lasso peptide precursors

Abstract

All Science Journal Classification (ASJC) codes

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