The relationship between the frequency distribution of Ascaris lumbricoides and the prevalence and intensity of infection in human communities

H. L. Guyatt, D. A.P. Bundy, G. F. Medley, B. T. Grenfell

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Observed field data from a range of geographically distinct human communities suggest a consistent non-linear relationship between prevalence and mean intensity of Ascaris lumbricoides infection. Utilizing the negative binomial distribution as a description of observed aggregation, maximum-likelihood analysis reveals that the degree of aggregation is a negative linear function of mean worm burden. The factors responsible for this relationship in human populations require further study but may involve some combination of (i) density-dependent reduction in worm numbers within individuals, (ii) density-dependent parasite-induced host mortality or (iii) self-treatment by heavily infected hosts. Variability in the degree of aggregation appears dependent on the level of infection in a community and independent of geographical differences in the host or parasite populations.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalParasitology
Volume101
Issue number1
DOIs
StatePublished - Aug 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Animal Science and Zoology
  • Infectious Diseases

Keywords

  • Ascaris lumbricoides
  • aggregation
  • density dependence
  • frequency distribution
  • geographical variation
  • maximum-likelihood

Fingerprint Dive into the research topics of 'The relationship between the frequency distribution of Ascaris lumbricoides and the prevalence and intensity of infection in human communities'. Together they form a unique fingerprint.

  • Cite this