The productive merger of iodonium salts and organocatalysis: A non-photolytic approach to the enantioselective α-trifluoromethylation of aldehydes

Anna E. Allen, David W.C. MacMillan

Research output: Contribution to journalArticle

272 Scopus citations

Abstract

An enantioselective organocatalytic α-trifluoromethylation of aldehydes has been accomplished using a commercially available, electrophilic trifluoromethyl source. The merging of Lewis acid and organocatalysis provides a new strategy for the enantioselective construction of trifluoromethyl stereogenicity, an important chiral synthon for pharmaceutical, materials, and agrochemical applications. This mild and operationally simple protocol allows rapid access to enantioenriched α-trifluoromethylated aldehydes through a nonphotolytic pathway.

Original languageEnglish (US)
Pages (from-to)4986-4987
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number14
DOIs
StatePublished - Apr 14 2010

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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