A series of substituted (α-alkylidene)tetrahydrofurans was prepared by tungsten catalyzed reaction of substituted hydroxyfuroic acids. These reactions likely involve β-lactone intermediates which decarboxylate under the reaction conditions, and rates for olefin synthesis correlated with donor properties of substituents at C(4).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry