The Pif1p subfamily of helicases: Region-specific DNA helicases?

Jessica B. Bessler, Jorge Z. Torre, Virginia A. Zakian

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


DNA helicases are required for DNA replication, recombination and repair. Despite a common enzymatic function - the ability to unwind duplex DNA - most helicases share only limited amino acid sequence similarity. Helicases that have significant sequence similarity define a subfamily. It remains unclear, however, how this sequence similarity relates to helicase function. The Saccharomyces cerevisiae Pif1p helicase is the prototype member of a helicase subfamily that is conserved from yeasts to humans. As the two Pif1p subfamily members studied to date affect the same DNA sequences, the amino acid similarity that defines this subfamily might reflect common substrates.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalTrends in Cell Biology
Issue number2
StatePublished - Feb 1 2001

All Science Journal Classification (ASJC) codes

  • Cell Biology


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