The p53 protein does not facilitate adenovirus type 5 replication in normal human cells

Jasdave S. Chahal, S. J. Flint

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Although several adenovirus type 5 (Ad5) proteins prevent deleterious consequences of activation of p53, it has been reported that viral replication proceeds more efficiently when human tumor cells produce wild-type compared to mutant p53. We have now exploited RNA interference and lentiviral vectors to achieve essentially complete knockdown of p53 in normal human cells: no effects on the kinetics or efficiency of viral gene expression or production of infectious particles were observed

Original languageEnglish (US)
Pages (from-to)6044-6046
Number of pages3
JournalJournal of virology
Volume87
Issue number10
DOIs
StatePublished - May 2013

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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