The neural basis for combinatorial coding in a cortical population response

Leslie C. Osborne, Stephanie E. Palmer, Stephen G. Lisberger, William Bialek

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

We have used a combination of theory and experiment to assess how information is represented in a realistic cortical population response, examining how motion direction and timing is encoded in groups of neurons in cortical area MT. Combining data from several single-unit experiments, we constructed model population responses in small time windows and represented the response in each window as a binary vector of 1s or 0s signifying spikes or no spikes from each cell. We found that patterns of spikes and silence across a population of nominally redundant neurons can carry up to twice as much information about visual motion than does population spike count, even when the neurons respond independently to their sensory inputs. This extra information arises by virtue of the broad diversity of firing rate dynamics found in even very similarly tuned groups of MT neurons. Additionally, specific patterns of spiking and silence can carry more information than the sum of their parts (synergy), opening up the possibility for combinatorial coding in cortex. These results also held for populations in which we imposed levels of nonindependence (correlation) comparable to those found in cortical recordings. Our findings suggest that combinatorial codes are advantageous for representing stimulus information on short time scales, even when neurons have no complicated, stimulus-dependent correlation structure.

Original languageEnglish (US)
Pages (from-to)13522-13531
Number of pages10
JournalJournal of Neuroscience
Volume28
Issue number50
DOIs
StatePublished - Dec 10 2008

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Correlated variability
  • Information theory
  • MT
  • Smooth pursuit
  • Spike trains
  • Visual motion

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