The nematode Caenorhabditis elegans as a model for aging research

Hildegard I.D. Mack; Thomas Heimbucher; Coleen T. Murphy

doi:10.1016/j.ddmod.2018.11.001

The nematode Caenorhabditis elegans as a model for aging research

Hildegard I.D. Mack
, Thomas Heimbucher
, Coleen T. Murphy

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

The nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans’ biology, and we describe the experimental toolbox available to study worm aging.

Original language	English (US)
Pages (from-to)	3-13
Number of pages	11
Journal	Drug Discovery Today: Disease Models
Volume	27
DOIs	https://doi.org/10.1016/j.ddmod.2018.11.001
State	Published - Mar 1 2018

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

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10.1016/j.ddmod.2018.11.001

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abstract = "The nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans{\textquoteright} biology, and we describe the experimental toolbox available to study worm aging.",

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AB - The nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans’ biology, and we describe the experimental toolbox available to study worm aging.

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The nematode Caenorhabditis elegans as a model for aging research

Abstract

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