The nematode Caenorhabditis elegans as a model for aging research

Hildegard I.D. Mack, Thomas Heimbucher, Coleen T. Murphy

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


The nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans’ biology, and we describe the experimental toolbox available to study worm aging.

Original languageEnglish (US)
Pages (from-to)3-13
Number of pages11
JournalDrug Discovery Today: Disease Models
StatePublished - Mar 1 2018

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery


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