TY - JOUR
T1 - The nematode Caenorhabditis elegans as a model for aging research
AU - Mack, Hildegard I.D.
AU - Heimbucher, Thomas
AU - Murphy, Coleen T.
N1 - Funding Information:
We thank Birgit Weinberger and Elisabeth Mack for helpful discussion. This work was supported by the NIH NIA 1R56AG047344-01A1 293 (C.T.M.) and the Glenn Foundation for Medical Research. C.T.M. is the Director of the Glenn Center for Aging Research at Princeton, which also supports TH. Research in H.I.D.M.’s lab is supported by a Young Investigator Start-up Grant from the University of Innsbruck , the Tyrolian Science Fund and the Aktion Daniel Swarovski . We apologize to all researchers whose work could not be discussed in this review due to space limitations.
Funding Information:
We thank Birgit Weinberger and Elisabeth Mack for helpful discussion. This work was supported by the NIH NIA 1R56AG047344-01A1 293 (C.T.M.)and the Glenn Foundation for Medical Research. C.T.M. is the Director of the Glenn Center for Aging Research at Princeton, which also supports TH. Research in H.I.D.M.’s lab is supported by a Young Investigator Start-up Grant from the University of Innsbruck, the Tyrolian Science Fund and the Aktion Daniel Swarovski. We apologize to all researchers whose work could not be discussed in this review due to space limitations.
Publisher Copyright:
© 2018
PY - 2018/3/1
Y1 - 2018/3/1
N2 - The nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans’ biology, and we describe the experimental toolbox available to study worm aging.
AB - The nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans’ biology, and we describe the experimental toolbox available to study worm aging.
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U2 - 10.1016/j.ddmod.2018.11.001
DO - 10.1016/j.ddmod.2018.11.001
M3 - Review article
AN - SCOPUS:85059466005
SN - 1740-6757
VL - 27
SP - 3
EP - 13
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
ER -