TY - JOUR
T1 - The nematode Caenorhabditis elegans as a model for aging research
AU - Mack, Hildegard I.D.
AU - Heimbucher, Thomas
AU - Murphy, Coleen T.
N1 - Publisher Copyright:
© 2018
PY - 2018/3/1
Y1 - 2018/3/1
N2 - The nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans’ biology, and we describe the experimental toolbox available to study worm aging.
AB - The nematode Caenorhabditis elegans is a key model system for experimental research on the genetic regulation of aging, and has paved the way towards many important discoveries in this field. Importantly, in the course of its short lifespan of ∼3 weeks, C. elegans displays many phenotypic, behavioral, and molecular changes that are widely shared among metazoans as they age. In this review, we summarize how aging research takes advantage of C. elegans’ biology, and we describe the experimental toolbox available to study worm aging.
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U2 - 10.1016/j.ddmod.2018.11.001
DO - 10.1016/j.ddmod.2018.11.001
M3 - Review article
AN - SCOPUS:85059466005
SN - 1740-6757
VL - 27
SP - 3
EP - 13
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
ER -