Background: The role of microRNA (miRNA)-23b/27b/24 in metastasis is controversial. Results: Ectopic expression of the miRNA-23b/27b/24 cluster enhances metastasis in vivo by direct inhibition of prosaposin (PSAP). Conclusion: PSAP is a metastasis suppressor that is targeted by miRNA-23b/27b/24 in breast cancer. Significance: This finding represents a novel miRNA-target interaction for therapeutic intervention of breast cancer metastasis.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology