The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin

Brian Ell, Qiong Qiu, Yong Wei, Laura Mercatali, Toni Ibrahim, Dino Amadori, Yibin Kang

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Background: The role of microRNA (miRNA)-23b/27b/24 in metastasis is controversial. Results: Ectopic expression of the miRNA-23b/27b/24 cluster enhances metastasis in vivo by direct inhibition of prosaposin (PSAP). Conclusion: PSAP is a metastasis suppressor that is targeted by miRNA-23b/27b/24 in breast cancer. Significance: This finding represents a novel miRNA-target interaction for therapeutic intervention of breast cancer metastasis.

Original languageEnglish (US)
Pages (from-to)21888-21895
Number of pages8
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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