@article{1c70b67a65e042e6a668bc25d8e9e626,
title = "The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog",
abstract = "The torpedo gene of Drosophila melanogaster is involved in the establishment of the dorsoventral pattern of eggshell and embryo. We have isolated new alleles of torpedo and have found that torpedo is allelic to the zygotic embryonic lethal faint little ball. We have shown that torpedo resides in subdivision 57F on the second chromosome - at the same location as the Drosophila homolog of the EGF receptor (DER). Using a cosmid that contains most of the DER coding region as a hybridization probe, we have shown that a cytologically small deficiency that eliminates torpedo activity also removes the DER gene, and that an inversion that was isolated as a strong torpedo allele breaks the coding region of the DER gene. We conclude that torpedo is the DER gene.",
author = "Price, {James V.} and Clifford, {Robert J.} and Trudi Sch{\"u}pbach",
note = "Funding Information: We would like to thank Dari Sweeton for excellent technical assistance with histology, and Eyai Schejter and Benny Shilo for laying the moiec-ular foundation for this work and for sharing their results prior to pubii-cation. We are grateful to Sam Wadsworth for generously providing the p13 DER fragment; to John Tamkun for kindly supplying the cosmid library; to Janis O{\textquoteright}Donnell and Robert Bosweli for providing stocks and for sharing the unpublished cytological information on their deficiencies; to Eric Wieschaus and Christiane Niisslein-Voihard for providing the f/b alleles; and to Lynn Manseau, Suki Parks, Mark Peifer, Marya Postner, and Eric Wieschaus for valuable comments on early versions of the manuscript. We would especially like to thank ail of the members of our lab and our colleagues at Princeton for stimulating discussions and support. This work was supported by grants from the National Science Foundation (#DCB-8505917) and the National institutes of Health (#GM40558-01) to T. S. J. V. P was supported by a postdoctoral fellowship from the American Cancer Society, and R. J. C. by an NIH Genetics Predoctorai Training Grant.",
year = "1989",
month = mar,
day = "24",
doi = "10.1016/0092-8674(89)90641-7",
language = "English (US)",
volume = "56",
pages = "1085--1092",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",
}