The many bits of positional information

Gašper Tkačik, Thomas Gregor

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Half a century after Lewis Wolpert's seminal conceptual advance on how cellular fates distribute in space, we provide a brief historical perspective on how the concept of positional information emerged and influenced the field of developmental biology and beyond. We focus on a modern interpretation of this concept in terms of information theory, largely centered on its application to cell specification in the early Drosophila embryo. We argue that a true physical variable (position) is encoded in local concentrations of patterning molecules, that this mapping is stochastic, and that the processes by which positions and corresponding cell fates are determined based on these concentrations need to take such stochasticity into account. With this approach, we shift the focus from biological mechanisms, molecules, genes and pathways to quantitative systems-level questions: where does positional information reside, how it is transformed and accessed during development, and what fundamental limits it is subject to?.

Original languageEnglish (US)
Article numberdev176065
JournalDevelopment (Cambridge)
Issue number2
StatePublished - Jan 2021

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology


  • Developmental biology
  • Drosophila embryo
  • Lewis Wolpert
  • Pattern formation
  • Shannon information


Dive into the research topics of 'The many bits of positional information'. Together they form a unique fingerprint.

Cite this