The mammalian embryo’s first agenda: Making trophectoderm

Eszter Posfai, Isidora Rovic, Andrea Jurisicova

Research output: Contribution to journalArticle

Abstract

One of the bottlenecks for a successful pregnancy in mammalian species is the implantation of the early embryo into the wall of the mother’s uterus.The first cell lineage the embryo sets aside following fertilization is the trophectoderm – a specialized cell type that establishes contact with the mother and mediates embryo implantation. We summarize the events that lead to the formation of the trophectoderm lineage in the preimplantation embryo and highlight key features of this cell type, which could be useful in the clinical setting for prediction of implantation outcomes.

Original languageEnglish (US)
Pages (from-to)157-170
Number of pages14
JournalInternational Journal of Developmental Biology
Volume63
Issue number3-5
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology

Keywords

  • Implantation
  • Inner cell mass
  • Preimplantation embryo
  • Trophectoderm

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