TY - JOUR
T1 - The life cycle and pathogenesis of human cytomegalovirus infection
T2 - Lessons from proteomics
AU - Jean Beltran, Pierre M.
AU - Cristea, Ileana M.
N1 - Publisher Copyright:
© 2014 Informa UK, Ltd.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate system-wide modulation of the human cell proteome. An impressive array of virus-host protein interactions occurs throughout the infection. To investigate the virus life cycle, proteomics has recently become a significant component of virology studies. Here, we review the mass spectrometry-based proteomics approaches used in HCMV studies, as well as their contribution to understanding the HCMV life cycle and the virus-induced changes to host cells. The importance of the biological insights gained from these studies clearly demonstrate the impact that proteomics has had and can continue to have on understanding HCMV biology and identifying new therapeutic targets.
AB - Viruses have coevolved with their hosts, acquiring strategies to subvert host cellular pathways for effective viral replication and spread. Human cytomegalovirus (HCMV), a widely-spread β-herpesvirus, is a major cause of birth defects and opportunistic infections in HIV-1/AIDS patients. HCMV displays an intricate system-wide modulation of the human cell proteome. An impressive array of virus-host protein interactions occurs throughout the infection. To investigate the virus life cycle, proteomics has recently become a significant component of virology studies. Here, we review the mass spectrometry-based proteomics approaches used in HCMV studies, as well as their contribution to understanding the HCMV life cycle and the virus-induced changes to host cells. The importance of the biological insights gained from these studies clearly demonstrate the impact that proteomics has had and can continue to have on understanding HCMV biology and identifying new therapeutic targets.
KW - CMV
KW - mass spectrometry
KW - post-translational modifications
KW - proteinprotein interactions
KW - proteomics
KW - virushost interactions
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U2 - 10.1586/14789450.2014.971116
DO - 10.1586/14789450.2014.971116
M3 - Review article
C2 - 25327590
AN - SCOPUS:84910670553
SN - 1478-9450
VL - 11
SP - 697
EP - 711
JO - Expert Review of Proteomics
JF - Expert Review of Proteomics
IS - 6
ER -