Abstract
The intramolecular asymmetric cyclization of aldehydes has been accomplished using singly occupied molecular orbital (SOMO) catalysis. Selective oxidation of chiral enamines (formed by the condensation of an aldehyde and a secondary amine catalyst) leads to the formation of a 3π-electron radical species. These chiral SOMO-activated radical cations undergo enantioselective cyclization with an array of pendent allylsilanes thus efficiently providing a new approach to the construction of five-, six- and seven-membered carbocycles and heterocycles.
Original language | English (US) |
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Pages (from-to) | 1470-1473 |
Number of pages | 4 |
Journal | Chemical Science |
Volume | 2 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2011 |
All Science Journal Classification (ASJC) codes
- Chemistry(all)