TY - JOUR
T1 - The Impact of Space and Time on the Functional Output of the Genome
AU - Nollmann, Marcelo
AU - Bennabi, Isma
AU - Götz, Markus
AU - Gregor, Thomas
N1 - Funding Information:
We thank Pau Bernado for his critical reading of the manuscript and for help with Figure 2J. This work was supported in part by the European Union’s Horizon 2020 Research and Innovation Program (Grant ID 724429) (M.N.), the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, Project ID 43147 1305) (M.G.), the Laboratoire d’Excellence Revive (Investissement d’Avenir; ANR-10-LABX-73) (I.B.), the U.S. National Science Foundation, through the Center for the Physics of Biological Function (PHY–1734030), and by National Institutes of Health Grants R01GM097275, U01DA047730, and U01DK127429 (T.G.).
Funding Information:
We thank Pau Bernado for his critical reading of the manuscript and for help with Figure 2J. This work was supported in part by the European Union’s Horizon 2020 Research and Innova- tion Program (Grant ID 724429) (M.N.), the Deutsche Forschungsgemeinschaft (DFG, Ger- man Research Foundation, Project ID 43147 1305) (M.G.), the Laboratoire d’Excellence Revive (Investissement d’Avenir; ANR-10-LABX-73) (I.B.), the U.S. National Science Foundation, through the Center for the Physics of Biological Function (PHY–1734030), and by National Institutes of Health Grants R01GM097275, U01DA047730, and U01DK127429 (T.G.).
Publisher Copyright:
© 2022 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2022/4
Y1 - 2022/4
N2 - Over the past two decades, it has become clear that the multiscale spatial and temporal organization of the genome has important implications for nuclear function. This review centers on insights gained from recent advances in light microscopy on our understanding of transcription. We discuss spatial and temporal aspects that shape nuclear order and their consequences on regulatory components, focusing on genomic scales most relevant to function. The emerging picture is that spatiotemporal constraints increase the complexity in transcriptional regulation, highlighting new challenges, such as uncertainty about how information travels from molecular factors through the genome and space to generate a functional output.
AB - Over the past two decades, it has become clear that the multiscale spatial and temporal organization of the genome has important implications for nuclear function. This review centers on insights gained from recent advances in light microscopy on our understanding of transcription. We discuss spatial and temporal aspects that shape nuclear order and their consequences on regulatory components, focusing on genomic scales most relevant to function. The emerging picture is that spatiotemporal constraints increase the complexity in transcriptional regulation, highlighting new challenges, such as uncertainty about how information travels from molecular factors through the genome and space to generate a functional output.
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U2 - 10.1101/cshperspect.a040378
DO - 10.1101/cshperspect.a040378
M3 - Article
C2 - 34230036
AN - SCOPUS:85120699790
SN - 1943-0264
VL - 14
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
IS - 4
M1 - a040378
ER -