TY - JOUR
T1 - The impact of hepatitis C virus entry on viral tropism
AU - Ding, Qiang
AU - Von Schaewen, Markus
AU - Ploss, Alexander
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/11/12
Y1 - 2014/11/12
N2 - Uptake of hepatitis C virus (HCV) into hepatocytes is an orchestrated process, involving numerous host factors, virion-associated lipoproteins, and a growing number of cell-associated factors. Several of these factors likely contribute to the hepatotropism and limited host range of this virus. Discerning the minimal set of human-specific factors required for viral uptake into nonhuman cells has facilitated the development of small animal models with inheritable HCV susceptibility. This review summarizes current knowledge of host factors required for HCV entry, the molecular mechanisms underlying HCV entry into hepatocytes, and aspects of viral entry contributing to HCV host tropism.
AB - Uptake of hepatitis C virus (HCV) into hepatocytes is an orchestrated process, involving numerous host factors, virion-associated lipoproteins, and a growing number of cell-associated factors. Several of these factors likely contribute to the hepatotropism and limited host range of this virus. Discerning the minimal set of human-specific factors required for viral uptake into nonhuman cells has facilitated the development of small animal models with inheritable HCV susceptibility. This review summarizes current knowledge of host factors required for HCV entry, the molecular mechanisms underlying HCV entry into hepatocytes, and aspects of viral entry contributing to HCV host tropism.
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U2 - 10.1016/j.chom.2014.10.009
DO - 10.1016/j.chom.2014.10.009
M3 - Review article
C2 - 25525789
AN - SCOPUS:84910600864
SN - 1931-3128
VL - 16
SP - 562
EP - 568
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 5
ER -