The histidine protein kinase superfamily

T. W. Grebe, J. B. Stock

Research output: Contribution to journalReview articlepeer-review

325 Scopus citations


Signal transduction in microorganisms and plants is often mediated by His - Asp phosphorelay systems. Two conserved families of proteins are centrally involved: histidine protein kinases and phospho-aspartyl response regulators. The kinases generally function in association with sensory elements that regulate their activities in response to environmental signals. A sequence analysis with 348 histidine kinase domains reveals that this family consists of distinct subgroups. A comparative sequence analysis with 298 available receiver domain sequences of cognate response regulators demonstrates a significant correlation between kinase and regulator subfamilies. These findings suggest that different subclasses of His - Asp phosphorelay systems have evolved independently of one another.

Original languageEnglish (US)
Pages (from-to)139-227
Number of pages89
JournalAdvances in Microbial Physiology
StatePublished - 1999

All Science Journal Classification (ASJC) codes

  • Physiology
  • Microbiology


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