Abstract
Signal transduction in microorganisms and plants is often mediated by His - Asp phosphorelay systems. Two conserved families of proteins are centrally involved: histidine protein kinases and phospho-aspartyl response regulators. The kinases generally function in association with sensory elements that regulate their activities in response to environmental signals. A sequence analysis with 348 histidine kinase domains reveals that this family consists of distinct subgroups. A comparative sequence analysis with 298 available receiver domain sequences of cognate response regulators demonstrates a significant correlation between kinase and regulator subfamilies. These findings suggest that different subclasses of His - Asp phosphorelay systems have evolved independently of one another.
Original language | English (US) |
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Pages (from-to) | 139-227 |
Number of pages | 89 |
Journal | Advances in Microbial Physiology |
Volume | 41 |
DOIs | |
State | Published - 1999 |
All Science Journal Classification (ASJC) codes
- Physiology
- Microbiology