The goldilocks principle and antibiotic resistance in bacteria

Qiucen Zhang; Kristelle Robin; David Liao; Guillaume Lambert; Robert H. Austin

doi:10.1021/mp200274r

The goldilocks principle and antibiotic resistance in bacteria

Qiucen Zhang
, Kristelle Robin
, David Liao
, Guillaume Lambert
, Robert H. Austin

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We have designed and fabricated a microecology to mimic a naturally occurring bacterial culture, which includes the stress gradient, metapopulation, and cellular motility. In this microecology, we show that it is possible to fix the resistance to the mutagenic antibiotic Ciprofloxacin in wild-type Escherichia coli within 10 h. We found the evolution of resistance is further accelerated in microecology if bacteria have already acquired the phenotype of growth advantage at the stationary phase (GASP).

Original language	English (US)
Pages (from-to)	2063-2068
Number of pages	6
Journal	Molecular Pharmaceutics
Volume	8
Issue number	6
DOIs	https://doi.org/10.1021/mp200274r
State	Published - Dec 5 2011

All Science Journal Classification (ASJC) codes

Drug Discovery
Molecular Medicine
Pharmaceutical Science

Keywords

antibiotics
evolution
resistance

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10.1021/mp200274r

Cite this

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AU - Zhang, Qiucen

AU - Robin, Kristelle

AU - Liao, David

AU - Lambert, Guillaume

AU - Austin, Robert H.

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Y1 - 2011/12/5

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AB - We have designed and fabricated a microecology to mimic a naturally occurring bacterial culture, which includes the stress gradient, metapopulation, and cellular motility. In this microecology, we show that it is possible to fix the resistance to the mutagenic antibiotic Ciprofloxacin in wild-type Escherichia coli within 10 h. We found the evolution of resistance is further accelerated in microecology if bacteria have already acquired the phenotype of growth advantage at the stationary phase (GASP).

KW - antibiotics

KW - evolution

KW - resistance

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UR - https://www.scopus.com/pages/publications/82955173051#tab=citedBy

U2 - 10.1021/mp200274r

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The goldilocks principle and antibiotic resistance in bacteria

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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