The goldilocks principle and antibiotic resistance in bacteria

Qiucen Zhang, Kristelle Robin, David Liao, Guillaume Lambert, Robert H. Austin

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We have designed and fabricated a microecology to mimic a naturally occurring bacterial culture, which includes the stress gradient, metapopulation, and cellular motility. In this microecology, we show that it is possible to fix the resistance to the mutagenic antibiotic Ciprofloxacin in wild-type Escherichia coli within 10 h. We found the evolution of resistance is further accelerated in microecology if bacteria have already acquired the phenotype of growth advantage at the stationary phase (GASP).

Original languageEnglish (US)
Pages (from-to)2063-2068
Number of pages6
JournalMolecular Pharmaceutics
Issue number6
StatePublished - Dec 5 2011

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Molecular Medicine
  • Pharmaceutical Science


  • antibiotics
  • evolution
  • resistance


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