The genetics of quantitative traits: Challenges and prospects

Trudy F.C. MacKay, Eric A. Stone, Julien F. Ayroles

Research output: Contribution to journalReview article

700 Scopus citations

Abstract

A major challenge in current biology is to understand the genetic basis of variation for quantitative traits. We review the principles of quantitative trait locus mapping and summarize insights about the genetic architecture of quantitative traits that have been obtained over the past decades. We are currently in the midst of a genomic revolution, which enables us to incorporate genetic variation in transcript abundance and other intermediate molecular phenotypes into a quantitative trait locus mapping framework. This systems genetics approach enables us to understand the biology inside the 'black box' that lies between genotype and phenotype in terms of causal networks of interacting genes.

Original languageEnglish (US)
Pages (from-to)565-577
Number of pages13
JournalNature Reviews Genetics
Volume10
Issue number8
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    MacKay, T. F. C., Stone, E. A., & Ayroles, J. F. (2009). The genetics of quantitative traits: Challenges and prospects. Nature Reviews Genetics, 10(8), 565-577. https://doi.org/10.1038/nrg2612