The Functional Neuroanatomy of Object Agnosia: A Case Study

Christina S. Konen, Marlene Behrmann, Mayu Nishimura, Sabine Kastner

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Cortical reorganization of visual and object representations following neural injury was examined using fMRI and behavioral investigations. We probed the visual responsivity of the ventral visual cortex of an agnosic patient who was impaired at object recognition following a lesion to the right lateral fusiform gyrus. In both hemispheres, retinotopic mapping revealed typical topographic organization and visual activation of early visual cortex. However, visual responses, object-related, and -selective responses were reduced in regions immediately surrounding the lesion in the right hemisphere, and also, surprisingly, in corresponding locations in the structurally intact left hemisphere. In contrast, hV4 of the right hemisphere showed expanded response properties. These findings indicate that the right lateral fusiform gyrus is critically involved in object recognition and that an impairment to this region has widespread consequences for remote parts of cortex. Finally, functional neural plasticity is possible even when a cortical lesion is sustained in adulthood. Video Abstract:

Original languageEnglish (US)
Pages (from-to)49-60
Number of pages12
JournalNeuron
Volume71
Issue number1
DOIs
StatePublished - Jul 14 2011

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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