The first Suzuki cross-couplings of aryltrimethylammonium salts

Simon B. Blakey, David W.C. MacMillan

Research output: Contribution to journalArticlepeer-review

323 Scopus citations


The first Suzuki cross-coupling reaction of aryltrimethylammonium triflates based on the use of an IMes·Ni(0) catalyst system is described. A wide range of electron-withdrawing and electron-donating substituents are tolerated on both the aryltrimethylammonium triflate and the boronic acid components of this reaction. In addition to arylboronic acids, the scope of the reaction is extended to encompass both boronate esters and alkenylboranes. This methodology constitutes a novel, mild method to activate anilines for metal-catalyzed cross-coupling reactions.

Original languageEnglish (US)
Pages (from-to)6046-6047
Number of pages2
JournalJournal of the American Chemical Society
Issue number20
StatePublished - May 21 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


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