The Evolution of Gene Regulation Underlies a Morphological Difference between Two Drosophila Sister Species

Sangyun Jeong, Mark Rebeiz, Peter Andolfatto, Thomas Werner, John True, Sean B. Carroll

Research output: Contribution to journalArticle

196 Scopus citations

Abstract

Understanding the mechanisms underlying the morphological divergence of species is one of the central goals of evolutionary biology. Here, we analyze the genetic and molecular bases of the divergence of body pigmentation patterns between Drosophila yakuba and its sister species Drosophila santomea. We found that loss of pigmentation in D. santomea involved the selective loss of expression of the tan and yellow pigmentation genes. We demonstrate that tan gene expression was eliminated through the mutational inactivation of one specific tan cis-regulatory element (CRE) whereas the Tan protein sequence remained unchanged. Surprisingly, we identify three independent loss-of-function alleles of the tan CRE in the young D. santomea lineage. We submit that there is sufficient empirical evidence to support the general prediction that functional evolutionary changes at pleiotropic loci will most often involve mutations in their discrete, modular cis-regulatory elements.

Original languageEnglish (US)
Pages (from-to)783-793
Number of pages11
JournalCell
Volume132
Issue number5
DOIs
StatePublished - Mar 7 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • DEVBIO
  • EVO_ECOL

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    Jeong, S., Rebeiz, M., Andolfatto, P., Werner, T., True, J., & Carroll, S. B. (2008). The Evolution of Gene Regulation Underlies a Morphological Difference between Two Drosophila Sister Species. Cell, 132(5), 783-793. https://doi.org/10.1016/j.cell.2008.01.014