The essential tension: opposed reactions in bacterial two-component regulatory systems

Frank D. Russo; Thomas J. Silhavy

doi:10.1016/0966-842X(93)90007-E

The essential tension: opposed reactions in bacterial two-component regulatory systems

Frank D. Russo, Thomas J. Silhavy

Molecular Biology

Research output: Contribution to journal › Review article › peer-review

101 Scopus citations

Abstract

In many different bacteria several sensory-response functions are controlled by systems of similar design. Most consist of two proteins, one of which regulates the phosphorylation of the other in response to an environmental stimulus. Regulation is achieved by balancing opposed phosphorylation and dephosphorylation reactions against each other. Remarkably, such a system can generate a signal whose strength is independent of the concentration of either component.

Original language	English (US)
Pages (from-to)	306-310
Number of pages	5
Journal	Trends in Microbiology
Volume	1
Issue number	8
DOIs	https://doi.org/10.1016/0966-842X(93)90007-E
State	Published - Nov 1993

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Virology
Microbiology

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10.1016/0966-842X(93)90007-E

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title = "The essential tension: opposed reactions in bacterial two-component regulatory systems",

abstract = "In many different bacteria several sensory-response functions are controlled by systems of similar design. Most consist of two proteins, one of which regulates the phosphorylation of the other in response to an environmental stimulus. Regulation is achieved by balancing opposed phosphorylation and dephosphorylation reactions against each other. Remarkably, such a system can generate a signal whose strength is independent of the concentration of either component.",

author = "Russo, {Frank D.} and Silhavy, {Thomas J.}",

note = "Funding Information: We thank Jeff Stock, LeslieP ratt and Lee Hartwell for critical reading of the manuscript. This work was supported by an NIH grant to T.J.S. (GM35791).",

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T2 - opposed reactions in bacterial two-component regulatory systems

AU - Russo, Frank D.

AU - Silhavy, Thomas J.

N1 - Funding Information: We thank Jeff Stock, LeslieP ratt and Lee Hartwell for critical reading of the manuscript. This work was supported by an NIH grant to T.J.S. (GM35791).

PY - 1993/11

Y1 - 1993/11

N2 - In many different bacteria several sensory-response functions are controlled by systems of similar design. Most consist of two proteins, one of which regulates the phosphorylation of the other in response to an environmental stimulus. Regulation is achieved by balancing opposed phosphorylation and dephosphorylation reactions against each other. Remarkably, such a system can generate a signal whose strength is independent of the concentration of either component.

AB - In many different bacteria several sensory-response functions are controlled by systems of similar design. Most consist of two proteins, one of which regulates the phosphorylation of the other in response to an environmental stimulus. Regulation is achieved by balancing opposed phosphorylation and dephosphorylation reactions against each other. Remarkably, such a system can generate a signal whose strength is independent of the concentration of either component.

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ER -

The essential tension: opposed reactions in bacterial two-component regulatory systems

Abstract

All Science Journal Classification (ASJC) codes

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