The essential tension: opposed reactions in bacterial two-component regulatory systems

Frank D. Russo, Thomas Joseph Silhavy

Research output: Contribution to journalReview article

85 Scopus citations

Abstract

In many different bacteria several sensory-response functions are controlled by systems of similar design. Most consist of two proteins, one of which regulates the phosphorylation of the other in response to an environmental stimulus. Regulation is achieved by balancing opposed phosphorylation and dephosphorylation reactions against each other. Remarkably, such a system can generate a signal whose strength is independent of the concentration of either component.

Original languageEnglish (US)
Pages (from-to)306-310
Number of pages5
JournalTrends in Microbiology
Volume1
Issue number8
DOIs
StatePublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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