The emerging role of nuclear viral DNA sensors

Benjamin A. Diner, Krystal K. Lum, Ileana M. Cristea

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Detecting pathogenic DNA by intracellular receptors termed "sensors" is critical toward galvanizing host immune responses and eliminating microbial infections. Emerging evidence has challenged the dogma that sensing of viral DNA occurs exclusively in sub-cellular compartments normally devoid of cellular DNA. The interferon-inducible protein IFI16 was shown tobind nuclear viral DNA and initiate immune signaling, culminating in antiviral cytokine secretion. Here, we review the newly characterized nucleus-originating immune signaling pathways, their links to other crucial host defenses, and unique mechanisms by which viruses suppress their functions. We frame these findings in the context of human pathologies associated with nuclear replicating DNA viruses.

Original languageEnglish (US)
Pages (from-to)26412-26421
Number of pages10
JournalJournal of Biological Chemistry
Issue number44
StatePublished - Oct 30 2015

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry
  • Cell Biology


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