The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis

Manav Korpal, Yibin Kang

Research output: Contribution to journalReview article

272 Scopus citations

Abstract

MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.

Original languageEnglish (US)
JournalRNA Biology
Volume5
Issue number3
DOIs
StatePublished - 2008

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • E-cadherin
  • Epithelial-mesenchymal transition
  • Metastasis
  • MicroRNA
  • ZEB

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