The effects of adrenal steroids and excitatory input on neuronal birth and survival

E. Gould, R. Gibbs, B. Moorjani, V. Luine

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

The dentate gyrus of the rat forms in three developmental phases, each of which is characterized by neuronal birth, migration and death. Recent evidence indicates that adrenal steroids regulate neuronal birth, death, and possibly migration throughout the life of the animal. However, the observation that very few neuroblasts in the developing or adult dentate gyrus express adrenal steroid receptors suggests that the effects of adrenal steroid manipulations on neurogenesis are indirect. Additional evidence indicates that NMDA receptor activation regulates neuronal birth and death in this brain region presenting the possibility that adrenal steroids influence these processes through direct actions on excitatory afferents. Future studies will address this possibility.

Original languageEnglish (US)
Pages (from-to)73-92
Number of pages20
JournalAnnals of the New York Academy of Sciences
Volume743
DOIs
StatePublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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