The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog

M. F. Semmelhack; J. J. Gallagher; W. D. Ding; G. Krishnamurthy; R. Babine; G. A. Ellestad

doi:10.1021/jo00095a002

The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog

M. F. Semmelhack
, J. J. Gallagher
, W. D. Ding
, G. Krishnamurthy
, R. Babine
, G. A. Ellestad

Chemistry

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The attachment of a simple 10-membered monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.

Original language	English (US)
Pages (from-to)	4357-4359
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	59
Issue number	16
DOIs	https://doi.org/10.1021/jo00095a002
State	Published - Aug 1 1994

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/jo00095a002

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title = "The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog",

abstract = "The attachment of a simple 10-membered monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.",

author = "Semmelhack, \{M. F.\} and Gallagher, \{J. J.\} and Ding, \{W. D.\} and G. Krishnamurthy and R. Babine and Ellestad, \{G. A.\}",

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AU - Semmelhack, M. F.

AU - Gallagher, J. J.

AU - Ding, W. D.

AU - Krishnamurthy, G.

AU - Babine, R.

AU - Ellestad, G. A.

PY - 1994/8/1

Y1 - 1994/8/1

N2 - The attachment of a simple 10-membered monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.

AB - The attachment of a simple 10-membered monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.

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U2 - 10.1021/jo00095a002

DO - 10.1021/jo00095a002

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SN - 0022-3263

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SP - 4357

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 16

ER -

The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog

Abstract

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