The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog

M. F. Semmelhack; J. J. Gallagher; W. D. Ding; G. Krishnamurthy; R. Babine; G. A. Ellestad

doi:10.1021/jo00095a002

The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog

M. F. Semmelhack, J. J. Gallagher, W. D. Ding, G. Krishnamurthy, R. Babine, G. A. Ellestad

Chemistry

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Abstract

The attachment of a simple 10-membered monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.

Original language	English (US)
Pages (from-to)	4357-4359
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	59
Issue number	16
DOIs	https://doi.org/10.1021/jo00095a002
State	Published - Aug 1 1994

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/jo00095a002

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title = "The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog",

abstract = "The attachment of a simple 10-membered monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.",

author = "Semmelhack, {M. F.} and Gallagher, {J. J.} and Ding, {W. D.} and G. Krishnamurthy and R. Babine and Ellestad, {G. A.}",

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AU - Gallagher, J. J.

AU - Ding, W. D.

AU - Krishnamurthy, G.

AU - Babine, R.

AU - Ellestad, G. A.

PY - 1994/8/1

Y1 - 1994/8/1

N2 - The attachment of a simple 10-membered monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.

AB - The attachment of a simple 10-membered monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.

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The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog

Abstract

All Science Journal Classification (ASJC) codes

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