The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog

Martin F. Semmelhack, J. J. Gallagher, W. D. Ding, G. Krishnamurthy, R. Babine, G. A. Ellestad

Research output: Contribution to journalArticle

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Abstract

The attachment of a simple 10-membered monocyclic 3-ene-1,5-diyne to a derivative of netropsin via two-carbon (acetate) and four-carbon (crotonate) tethers enhances the DNA cleavage potency, by a factor of almost 2000 in the best case.

Original languageEnglish (US)
Pages (from-to)4357-4359
Number of pages3
JournalJournal of Organic Chemistry
Volume59
Issue number16
DOIs
StatePublished - Aug 1 1994

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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