The effect of heterogeneity in measles vaccination on population immunity

K. Glass, J. Kappey, B. T. Grenfell

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


High overall vaccination levels sometimes hide pockets of poor coverage. We adopted a meta-population framework to model local aggregation of populations, and used this to investigate the effects of vaccination heterogeneity. A recent survey of antibody levels in a community with low vaccination levels in The Netherlands enabled us to assess the relative importance of local and long-range infective contacts, and thus identify feasible levels of aggregation in the meta-population model. In the aggregated model, we found that heterogeneity in vaccination coverage can lead to a much increased rate of infection among unvaccinated individuals, with a simultaneous drop in the average age at infection.

Original languageEnglish (US)
Pages (from-to)675-683
Number of pages9
JournalEpidemiology and Infection
Issue number4
StatePublished - Aug 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Epidemiology


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