The dynamics of infection and disease in bancroftian filariasis

A. Srividya, S. P. Pani, P. K. Rajagopalan, D. A.P. Bundy, B. T. Grenfell

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

This study examines the relationship between the dynamics of Wuchereria bancrofti infection and the development of chronic lymphatic disease. Data sets from Pondicherry, south India, and Calcutta are used to estimate the age-specific proportion of the endemic population which has converted from microfilaria positive to amicrofilaraemia, and is assumed to be at risk of disease. For men, but not women, the age-prevalence profile of the estimated population at risk’ is shown to correspond closely to the observed age-prevalence of chronic lymphatic disease in the same community. For both sexes, and independent of age, approximately 11% of the population at risk eventually develop lymphoedema. These observations suggest that filariasis endemic populations consist of those individuals who remain amicrofilaraemic and asymptomatic, and those who progress through the sequence: uninfected, microfilaraeinic, amicrofilar- aemic, to develop irreversible obstructive lymphatic pathology.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume85
Issue number2
DOIs
StatePublished - Mar 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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