TY - JOUR
T1 - The dynamics of chromatin condensation
T2 - Redistribution of topoisomerase II in the 87A7 heat shock locus during induction and recovery
AU - Udvardy, Andor
AU - Schedl, Paul
PY - 1993/12
Y1 - 1993/12
N2 - We have examined the in vivo sites of action for topoisomerases II in the 87A7 heat shock locus as a function of gene activity. When the hsp70 genes are induced, there is a dramatic redistribution of topoisomerase II in the locus which parallels many of the observed alterations in chromatin structure. In addition to changes in the topoisomerase II distribution within the locus, we find topoisomerase II localized around the putative domain boundaries scs and scs′. During recovery, when the chromatin fiber of the locus recondenses, the major sites of action for topoisomerase II appear to be located within the two hsp70 genes and in the intergenic spacer separating the two genes.
AB - We have examined the in vivo sites of action for topoisomerases II in the 87A7 heat shock locus as a function of gene activity. When the hsp70 genes are induced, there is a dramatic redistribution of topoisomerase II in the locus which parallels many of the observed alterations in chromatin structure. In addition to changes in the topoisomerase II distribution within the locus, we find topoisomerase II localized around the putative domain boundaries scs and scs′. During recovery, when the chromatin fiber of the locus recondenses, the major sites of action for topoisomerase II appear to be located within the two hsp70 genes and in the intergenic spacer separating the two genes.
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U2 - 10.1128/MCB.13.12.7522
DO - 10.1128/MCB.13.12.7522
M3 - Article
C2 - 8246970
AN - SCOPUS:0027367939
SN - 0270-7306
VL - 13
SP - 7522
EP - 7530
JO - Molecular and cellular biology
JF - Molecular and cellular biology
IS - 12
ER -