The Drosophila Myc gene, diminutive, is a positive regulator of the Sex-lethal establishment promoter, Sxl-Pe

Gretchen Kappes, Girish Deshpande, Brett B. Mulvey, Jamila I. Horabin, Paul Schedl

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The binary switch gene Sex-lethal (Sxl) controls sexual identity in Drosophila. When activated, Sxl imposes female identity, whereas male identity ensues by default when the gene is off. The decision to activate Sxl is controlled by an X chromosome counting system that regulates the Sxl establishment promoter, Sxl-Pe. The counting system depends upon the twofold difference in the gene dose of a series of X-linked transcription factors or numerators. Because of this difference in dose, early female embryos express twice the amount of these transcription factors, and the cumulative action of these transcription factors turns on Sxl-Pe. Here we show that the Drosophila Myc gene diminutive is an X-linked numerator.

Original languageEnglish (US)
Pages (from-to)1543-1548
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number4
DOIs
StatePublished - Jan 25 2011

All Science Journal Classification (ASJC) codes

  • General

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