TY - JOUR
T1 - The Dlk1 and Gtl2 genes are linked and reciprocally imprinted
AU - Schmidt, Jennifer V.
AU - Matteson, Paul G.
AU - Jones, Beverly K.
AU - Guan, Xiao Juan
AU - Tilghman, Shirley Marie
PY - 2000/8/15
Y1 - 2000/8/15
N2 - Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.
AB - Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.
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M3 - Article
C2 - 10950864
AN - SCOPUS:0034663920
SN - 0890-9369
VL - 14
SP - 1997
EP - 2002
JO - Genes and Development
JF - Genes and Development
IS - 16
ER -