The Dlk1 and Gtl2 genes are linked and reciprocally imprinted

Jennifer V. Schmidt, Paul G. Matteson, Beverly K. Jones, Xiao Juan Guan, Shirley Marie Tilghman

Research output: Contribution to journalArticlepeer-review

278 Scopus citations


Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.

Original languageEnglish (US)
Pages (from-to)1997-2002
Number of pages6
JournalGenes and Development
Issue number16
StatePublished - Aug 15 2000

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology


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