The Dlk1 and Gtl2 genes are linked and reciprocally imprinted

Jennifer V. Schmidt; Paul G. Matteson; Beverly K. Jones; Xiao Juan Guan; Shirley M. Tilghman

The Dlk1 and Gtl2 genes are linked and reciprocally imprinted

Jennifer V. Schmidt, Paul G. Matteson, Beverly K. Jones, Xiao Juan Guan, Shirley M. Tilghman

Research output: Contribution to journal › Article › peer-review

Abstract

Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.

Original language	English (US)
Pages (from-to)	1997-2002
Number of pages	6
Journal	Genes and Development
Volume	14
Issue number	16
State	Published - Aug 15 2000

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

Keywords

Dlk1
Genomic imprinting
Gtl2

Cite this

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abstract = "Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.",

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AU - Jones, Beverly K.

AU - Guan, Xiao Juan

AU - Tilghman, Shirley M.

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AB - Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.

KW - Dlk1

KW - Genomic imprinting

KW - Gtl2

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ER -

The Dlk1 and Gtl2 genes are linked and reciprocally imprinted

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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