The diffusive way out: Herpesviruses remodel the host nucleus, enabling capsids to access the inner nuclear membrane

Jens B. Bosse, Lynn W. Enquist

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Herpesviruses are large DNA viruses that utilize the host nucleus for genome replication as well as capsid assembly. After maturation, these 125 nm large capsid assemblies must cross the nucleoplasm to engage the nuclear envelope and bud into the cytoplasm. Here we summarize our recent findings how this motility is facilitated. We suggest that herpesvirus induced nuclear remodeling allows capsids to move by diffusion in the nucleus and not by motor-dependent transport.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalNucleus
Volume7
Issue number1
DOIs
StatePublished - Mar 1 2016

All Science Journal Classification (ASJC) codes

  • Cell Biology

Keywords

  • capsid
  • egress
  • herpes
  • nuclear actin
  • nucleus
  • ring-sheet

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